Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RAArticle Published on 2022-09-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] 1,25-dihydroxy vitamin D3 activated acute respiratory syndrome analyses Analysis applied autoimmune conditions Bacteremia Bacterial Bacterial infection Bacterial infections Bioinformatics analysis Biomarker caused Cell cell membrane CIBERSORT conducted coronavirus COVID-19 Cytoscape database dataset datasets DEGs dendritic cell dendritic cells dendritic cells. differentially expressed differentially expressed gene disease DNA drug target Effectiveness examined expression FIVE functional enrichment Functional enrichment analysis GBP1 gene network GeneMANIA Genes global pandemic HERC5 humans identify Ifi44 IFI44L IFIT3 IFIT5 IFN signaling IFN signaling pathway IFN-α/β Immune cell infiltration immune cells Immune escape immune evasion immune system Immunological response Infection infections infiltration Intersection ISG15 KEGG mechanism miRNA molecular mechanism molecular target NLR OAS1 oxidative phosphorylation pathogenic bacteria pathway Patient platform positive correlation PPI network prevalent proliferation promote regulate Regulation Rheumatoid rheumatoid arthritis risk factor ROC curves RSAD2 Rtp4 SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease signaling pathway Staphylococcus Staphylococcus aureus target the SARS-CoV-2 therapeutic viral infection viral replication virus were used YY1 [DOI] 10.3389/fimmu.2022.1013322 PMC 바로가기
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Research Published on 2022-07-282022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] acute infection acute respiratory distress Amino acid Analysis Applying ARDS carbon source CD4+ T cell CD4+ T cells COVID-19 Glycolysis highlight host adaptation immune response Impaired individual induce infected with SARS-CoV-2 infections influence interferon-γ ketogenic metabolism mice Mortality oxidative phosphorylation Patient promote provide Pulmonary infection pulmonary viral reducing severe COVID-19 severe respiratory infections skewed survival syndrome T cell T cell dysfunction T cell response [DOI] 10.1038/s41586-022-05128-8 [Article Type] Research
Cytidine 5′-Diphosphocholine Corrects Alveolar Type II Cell Mitochondrial Dysfunction in Influenza-infected MiceArticle Published on 2022-06-012023-06-23 Journal: American Journal of Respiratory Cell and Molecular [Category] 신종인플루엔자, [키워드] cardiolipin Glycolysis oxidative phosphorylation Phospholipids. [DOI] 10.1165/rcmb.2021-0512OC PMC 바로가기
Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogrammingIRAK4의 억제는 SARS-CoV-2 스파이크 단백질 유도 대식세포 염증 및 해당과정 재프로그래밍을 조절하지 못함Article Published on 2022-05-192022-09-11 Journal: Cellular and Molecular Life Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 activate AKT baseline blockade CCL2 cells citrate counteract Critical dysregulated ERK expression Glycolysis human SARS-CoV-2 Hyperactivation IL-6 IL-8 impair independent Inflammatory Inflammatory marker inflammatory markers inhibition inhibitor Innate immunity irak4 IRAK4 inhibitor IRF5 IRF7 knockdown Lactate LDHA Macrophage macrophages metabolic activity mitochondrial Mitochondrial oxidative phosphorylation molecular mechanism monokines murine models NF-κB NF-κB activation oxidative oxidative phosphorylation phenotype Phosphorylation promoted Protein reduction response responsible reversal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 patient severe COVID-19 patients shown Signaling siRNA spike Spike protein succinate suppression Therapeutic strategies therapy TLR TLR-mediated TLR2 TLR7 TLRs TLRs. TNFα treated Treatment triggered without affecting [DOI] 10.1007/s00018-022-04329-8 PMC 바로가기 [Article Type] Article
MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granulesResearch Article Published on 2022-02-062022-10-28 Journal: Virulence [Category] COVID-19, [키워드] Act Actinomycin Analysis Antigen presentation Cell Cell migration cells cellular complex death downregulated downregulating explain Genes Granule impair Inflammatory inhibit LLPS Lysosomes mass spectrometry mechanism MERS-CoV MERS-CoV infection metabolic processe metabolic processes Middle East mRNA non-structural protein nsp1 oxidative phosphorylation P-bodies Protein Regulatory respiratory syndrome coronavirus ribosomal protein ribosome RNA sensitivity Sequencing shown stress granule stress granules transcriptional transgenic mice upregulated viability [DOI] 10.1080/21505594.2022.2032928 PMC 바로가기 [Article Type] Research Article
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3Article Published on 2022-01-252023-06-13 Journal: Cell Reports [Category] B형 간염, Fulltext, [키워드] Hepatitis B virus IL-1β signaling M1-like and M2-like macrophages metabolic reprogramming oxidative phosphorylation Transcriptional regulation. [DOI] 10.1016/j.celrep.2021.110284 PMC 바로가기
Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii전체 게놈 시퀀싱 및 전 사체의 통합은 주요 말라리아 벡터 Anopheles coluzzii에서 살충제 저항성의 재건에 대한 복잡한 그림을 보여줍니다.Research Article Published on 2021-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Anophele approach block change changes in colony complex complexity determine diagnostic Diagnostic markers elevated expression of gene Genetic genetic background Genome genomic genomic change increase in increased respiratory rate increasingly insecticide integration inversion Laboratory malaria malaria control malaria vector marker mechanism metabolism microbial Microbiome original oxidative phosphorylation pathway phenotype Population Pyrethroids respiratory rate reveal RNAseq Sequencing subject subset susceptible Transcriptome transcriptomic transcriptomics translated whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1009970 PMC 바로가기 [Article Type] Research Article
Niclosamide for Covid-19: bridging the gapCovid-19용 니클로사미드: 격차 해소Review Published on 2021-12-012022-09-11 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] acute respiratory distress syndrome angiotensin Angiotensin-converting enzyme anthelminthic Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Antiviral antiviral activities Antiviral effect antiviral effects biological processes clinical outcomes clinical study clinical trial clinical trials Concentration concerning COVID-19 COVID-19 severity Cytokines Cytopathic effect Direct disease distress Effect endosomal pH enzyme Google Scholar homeostasis immune in vivo Inflammasome inflammatory signaling inhibit interruption mandatory maturation mechanism modulate modulating mTOR mTOR signaling NCL neutralization NF-κB niclosamide NLRP3 NLRP3 inflammasome oral bioavailability oxidative phosphorylation pandemic pathway Patient pleiotropic pro-inflammatory cytokines Prospective protective role reduce reducing Regulatory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. Science Science Direct serum severity signaling pathway suppression therapeutic therapy treat viral proliferation Viral protein was done Web of Science [DOI] 10.1007/s11033-021-06770-7 PMC 바로가기 [Article Type] Review
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1Immunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2-deoxyglucose 2-DG binding blocked COVID-19 cytokine cytokine production dependent on Deprivation direct infection dose-dependent drug experiments Glucose Glycolysis hallmark hyperinflammation hyperinflammatory state immunometabolism implication increase in induce Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibition live SARS-CoV-2 metabolism metformin mitochondrial metabolism monocyte oxidative phosphorylation pro-inflammatory pro-inflammatory cytokines regulate rescued SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 strain severity spike Spike protein stimulated subunit suppresse suppressed the SARS-CoV-2 Treatment undergo upregulating viral spike protein WA1/2020 [DOI] 10.3389/fimmu.2021.733921 PMC 바로가기 [Article Type] Immunology